CovidV1, Main, Exploration, bibRecord, 000C35

Organ-specific features of natural killer cells

Identifieur interne : 000C35 ( Main/Exploration ); précédent : 000C34; suivant : 000C36

Organ-specific features of natural killer cells

Auteurs : Fu-Dong Shi [République populaire de Chine, États-Unis] ; Hans-Gustaf Ljunggren [Suède] ; Antonio La Cava [États-Unis] ; Luc Van Kaer [États-Unis]

Source :

Nature reviews. Immunology [ 1474-1733 ] ; 2011.

RBID : PMC:3620656

Abstract

Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the earliest arrivals at target organs of disease. However, the role of NK cells in mounting inflammatory responses is often complex and sometimes paradoxical. Here, we examine the divergent phenotypic and functional features of NK cells, as deduced largely from experimental mouse models of pathophysiological responses in the liver, mucosal tissues, uterus, pancreas, joints and brain. Moreover, we discuss how organ-specific factors, the local microenvironment and unique cellular interactions may influence the organ-specific properties of NK cells.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620656

DOI: 10.1038/nri3065
PubMed: 21941294
PubMed Central: 3620656

Affiliations:

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Organ-specific features of natural killer cells

Organ-specific features of natural killer cells

Source :

Abstract

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